The appearance of COVID-19 around the world has highlighted the need for more and better hygiene infrastructures. Disinfectants, surface coatings and antimicrobial compounds have seen rapid advancements over the past two years, all aimed at preventing the spread of infections. A British company, BioInteractions, leads the charge with its innovative antimicrobial medical materials.
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BioInteractions: innovators in healthcare materials
BioInteractions, based in Reading, near London, UK, is at the forefront of antimicrobial technology. Its products – health and hygiene solutions – fight the transmission of infections from skin to skin and on surfaces.
The company’s base in Berkshire is home to state-of-the-art production and R&D facilities built around its team of specialists. The core business revolves around BioInteractions’ expertise in medical coating materials. These products kill bacteria, viruses and other germs on surfaces while simultaneously reducing the risk of infection or rejection of implanted devices.
R&D, as well as large-scale production, is carried out at the Reading Science and Technology Center, which is home to a conglomerate of cutting-edge manufacturing and research organizations.
A custom-designed production laboratory on this site enables BioInteractions to undertake highly sophisticated operations using a wide range of state-of-the-art equipment. On-site equipment includes fully customized polymerization platforms and analytical resources such as FT-IR and GPC.
The company celebrated its 30th anniversary this year.
BioInteractions partners with major manufacturers around the world, producing hygienic coating materials for cardiothoracic surgery, in vitro diagnostics, catheters and long-term implantable medical devices like vascular grafts.
The company also works with established external laboratories to support its analytical and quality testing operations.
TridAnt: the disinfectant that continues to disinfect
Building on three decades of experience providing biocompatible materials for the global medical and pharmaceutical industries, BioInteractions recently launched a new product that continues to disinfect surfaces after application. The technology means that skin contact disinfects rather than contaminates uncoated surfaces, protecting people after they stop washing their hands.
Further Reading: Could a New Antimicrobial Coating From Tree Protein Improve Masks?
The material is called TridAnt and is the company’s latest coating for medical devices. The product includes a prevention infrastructure that uses the company’s expertise and existing technological innovation to achieve unmatched efficiency.
TridAnt continues to kill 99.999% of gram-negative and gram-positive bacteria, as well as yeast, for up to 100 days after application. It is the only material available that offers this level of antimicrobial resistance for that long.
BioInteractions says TridAnt could help the healthcare industry prevent infections, fight the transmission of pathogens between people, and fight antimicrobial resistance. Together, all these factors could allow the development of new procedures and treatments that were previously too risky.
The material includes a highly efficient mechanism that kills a broad spectrum of pathogens as soon as they interact with the coated surface. The active and passive components of the material work together to prevent deposition, protect against adhesion, and kill pathogens on contact.
TridAnt is biocompatible and non-leaching. This helps ensure patient safety while effectively targeting the harmful microbes that cause infections.
The TridAnt line of skin protection product – combined with an improved washing routine – keeps germs out of human skin, even with skin-to-skin contact. TridAnt on the skin starts to protect you as soon as you stop washing, and it continues to work for up to 48 hours after application.
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Building on BioInteractions’ extensive portfolio of biocompatible, leach-free coatings, TridAnt offers increased resistance to infection for long periods of time. It causes bacteria to physically lysis, preventing them from infecting surfaces of medical devices or other people.
TridAnt does not use any toxic or eluting components. This is a significant advance in antimicrobial technology for medical devices.
Antimicrobial coating materials
Materials science is important for the development of antimicrobial technologies. The antimicrobial performance of materials relies on critical interactions between the pathogen and the surface interface. Successful antimicrobial coatings are designed taking into account a complex variety of biological events occurring at this interface.
Factors that complicate events at the pathogen-surface interface include surface properties such as topography, wettability and composition, protein behaviors, and the biological entities present.
Effective antimicrobial coatings must act against a wide range of pathogens to meet the demands of medical devices. They must also provide long-lasting protection, minimizing implementation costs, as well as safe and biocompatible variants to enable large-scale applications.
The multi-action materials used by BioInteractions are biocompatible and non-leaching – they stay on the surface they are applied to and do not adversely affect it. This is especially important for medical devices, which must be accepted by the patient’s body and remain there for a long time.
The high efficacy against a broad spectrum of pathogens and the long duration of this efficacy also reduce the need for antibiotics in patients. This can help tackle the growing problem of antibiotic resistance in the global human population.
Next steps for biointeractions
BioInteractions is focused on improving hygiene routines for individuals, organizations and communities to complement its line of antimicrobial coating products. The combination of innovative materials with improved routines will lead to a “gold standard” in hygiene and health care, according to the company.
In the long term, BioInteractions says its infection prevention work will steer them towards long-term prevention mechanisms and improved medical devices. The materials they develop for antimicrobial coatings can also be applied to industrial and consumer products.
References and further reading
BioInteractions (2021). “How new medical device technology combats disease transmission while improving health and hygiene infrastructure”. Medical device network. Available online: https://www.medicaldevice-network.com/sponsored/stopping-the-spread/.
Luthra, A. (2021). “Kill the germs inside you, on you and around you.” Medical Plastics News. Available online: https://www.medicalplasticsnews.com/medical-plastics-industry-insights/medical-plastics-materials-insights/tridant-%E2%80%94-enhanced-antimicrobial-biocompatibility-on-medical/.